Interesting paper below (after the key points).

Thank you Sara Jenks for forwarding the Key messages to me:

🛑KEY POINTS OF THIS EXCELLENT READ FROM #LANCET.🛑

⭐Clinical course and risk factors for mortality in #COVID_19

👉The shortest observed duration of viral shedding among survivors was 8 days, whereas the longest was 37 days. The median duration of viral shedding was 20·0 days.

👉Baseline lymphocyte count was significantly higher in survivors than non-survivors; it also improved with time in survivors.

👉Levels of d-dimer, high-sensitivity cardiac troponin I, serum ferritin, lactate dehydrogenase, and IL-6 were clearly elevated in non-survivors compared with survivors. and increased with illness deterioration.

👉Median time from illness onset to dyspnoea was similar in survivors and non-survivors, with a median duration of dyspnoea of 13·0 days.

👉Sepsis developed at a median of 9·0 days (7·0–13·0) after illness onset among all patients, followed by ARDS (12·0 days [8·0–15·0]), acute cardiac injury (15·0 days [10·0–17·0]), acute kidney injury (15·0 days [13·0–19·5]), and secondary infection (17·0 days [13·0–19·0]).

👉The median time from dyspnoea to intubation was 10·0 days.

👉Older age, d-dimer levels greater than 1 μg/mL, and higher SOFA score on admission were associated with higher odds of in-hospital death.

👉Increased high-sensitivity cardiac troponin I during hospitalization was found in more than half of those who died.

👉D-dimer greater than 1 µg/mL is associated with a fatal outcome of COVID-19.

👉More than half of the patients developed sepsis.

👉More than 70% of patients had white blood cell count below 10·0 × 10⁹ per L or procalcitonin below 0·25 ng/mL, and no bacterial pathogens were detected in these patients.

👉The median time from illness onset (ie, before admission) to discharge was 22·0 days whereas the median time to death was 18·5 days.